vadastuximab talirine

Ligand id: 9434

Name: vadastuximab talirine

Classification
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
International Nonproprietary Names
INN number INN
9983 vadastuximab talirine
Synonyms
SGN-CD33A
Database Links
Specialist databases
IMGT/mAb-DB 552
Other databases
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Comments
Vadastuximab talirine (SGN-CD33A; Seattle Genetics) is an humanized anti-CD33 antibody-drug conjugate (ADC) which delivers a toxic payload to CD33 +ve cells [1]. Talirine is a pyrrolobenzodiazepine (PBD) dimer (PubChem CID 45257190), which is a DNA crosslinking agent, causing DNA damage and ultimately apoptosis of targeted cells. Talirine is conjugated to engineered Cys residues in the antibody via a cathepsine B cleavable linker.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.