ω-agatoxin IVA   Click here for help

GtoPdb Ligand ID: 2529

Synonyms: omega-Aga-IVA | Omega-agatoxin-Aa4a
Comment: From the venom of Agelenopsis aperta (North American funnel-web spider)
Click here for help
Bioactivity Comments
ω-agatoxin IVA has been described as a gating modifier of Cav2.1 [2].
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Cav2.1 Rn Gating inhibitor Antagonist 7.0 – 8.7 pIC50 - 1,3
pIC50 7.0 – 8.7 (IC50 1x10-7 – 2x10-9 M) P current component: Kd =~2nM, Q component Kd= >100nM [1,3]
Voltage: -100.0 – -90.0 mV