labetuzumab   Click here for help

GtoPdb Ligand ID: 8251

Synonyms: CEACIDE® | hMN14
Compound class: Antibody
Comment: Labetuzumab is a humanised mouse monoclonal antibody targeting CEACAM5 (CD66e), a tumour marker that can be measured in serum.
Labetuzumab can be labelled with radioactive isotopes such as yttrium-90 and iodine-131, providing targeted radioimmumotherapy.
Labetuzumab has been used to generate an antibody-drug conjugate (ADC) called labetuzumab govitecan, in which the antibody is covalently bound to SN-38, the active metabolite of the topoisomerase inhibitor, irinotecan.
No information available.
Summary of Clinical Use Click here for help
Phase 2 clinical trials assessing labetuzumab for cancer indications, including colorectal, breast and pancreatic cancers have been completed.