endothelin-3   Click here for help

GtoPdb Ligand ID: 1004

Abbreviated name: ET-3
Compound class: Endogenous peptide in human, mouse or rat
Comment: The human ET-3 sequence is identical to the mouse and rat ET-3 sequences.
Species: Human, Mouse, Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Davenport AP. (1997)
Distribution of endothelin receptors.  In  Endothelins in Biology and Medicine
Edited by Mille R, Pelton JT, Huggins J (CRC Press.) 45-68. [ISBN:0849369754]
2. Kilpatrick SJ, Roberts JM, Lykins DL, Taylor RN. (1993)
Characterization and ontogeny of endothelin receptors in human placenta.
Am J Physiol, 264 (3 Pt 1): E367-72. [PMID:8460684]
3. Kondo S, Morita T, Tashima Y. (1994)
Endothelin receptor density in human hypertrophic and non-hypertrophic prostate tissue.
Tohoku J Exp Med, 172 (4): 381-4. [PMID:7524189]
4. Maguire JJ, Davenport AP. (1995)
ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro.
Br J Pharmacol, 115 (1): 191-7. [PMID:7647976]
5. Russell FD, Davenport AP. (1996)
Characterization of the binding of endothelin ETB selective ligands in human and rat heart.
Br J Pharmacol, 119 (4): 631-6. [PMID:8904635]
6. Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. (1990)
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor.
Nature, 348 (6303): 732-5. [PMID:2175397]
7. Williams Jr DL, Jones KL, Pettibone DJ, Lis EV, Clineschmidt BV. (1991)
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes.
Biochem Biophys Res Commun, 175 (2): 556-61. [PMID:1850245]