α-CGRP   Click here for help

GtoPdb Ligand ID: 681

Synonyms: α-calcitonin gene-related peptide (αCGRP, human) | calcitonin gene-related peptide 1 (CGRP)
Compound class: Endogenous peptide in human, mouse or rat
Comment: This peptide is an isoform of calcitonin, encoded by the same gene and produced by alternative splicing. Please note that each peptide is represented by a different UniProt ID.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: α-cgrp

References
1. Aiyar N, Disa J, Pullen M, Nambi P. (2001)
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.
Mol Cell Biochem, 224 (1-2): 123-33. [PMID:11693189]
2. Benschop RJ, Gehlert DR, Merchant KM, Shanafelt AB. (2007)
Treatment of migraine with anti-CGRP antibodies.
Patent number: WO2007076336 A1. Assignee: Eli Lilly Co., Benschop RJ, Gehlert DR, Merchant KM, Shanafelt AB. Priority date: 22/12/2005. Publication date: 05/07/2007.
3. Fraser NJ, Wise A, Brown J, McLatchie LM, Main MJ, Foord SM. (1999)
The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.
Mol Pharmacol, 55: 1054-1059. [PMID:10347248]
4. Garcia-Martinez LF, Kaiser EA, Kovacevich BR, Kuburas A, Latham JA, Raddant AC, Recober A, Russo AF, Smith JTL. (2012)
Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers.
Patent number: WO2012162257A2. Assignee: Alderbio Holdings Llc, The University Of Iowa Research Foundation. Priority date: 20/05/2011. Publication date: 29/11/2012.
5. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM. (2005)
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Mol Pharmacol, 67 (5): 1655-65. [PMID:15692146]
6. Kuwasako K, Cao YN, Nagoshi Y, Tsuruda T, Kitamura K, Eto T. (2004)
Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.
Mol Pharmacol, 65 (1): 207-13. [PMID:14722252]
7. Kuwasako K, Kitamura K, Nagoshi Y, Eto T. (2003)
Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Biochem Biophys Res Commun, 301 (2): 460-4. [PMID:12565884]
8. Leuthauser K, Gujer R, Aldecoa A, McKinney RA, Muff R, Fischer JA, Born W. (2000)
Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.
Biochem J, 351: 347-351. [PMID:11023820]
9. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998)
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Nature, 393 (6683): 333-9. [PMID:9620797]
10. Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL. (2015)
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
Ann Clin Transl Neurol, 2 (6): 595-608. [PMID:26125036]
11. Zeller J, Poulsen KT, Abdiche YN, Pons J, Collier SJ, Rosenthal A. (2007)
Antagonist antibodies directed against calcitonin gene-related peptide and methods using same.
Patent number: WO2007054809. Assignee: Rinat Neuroscience Corp.. Priority date: 14/11/2005. Publication date: 18/05/2007.
12. Zimmermann U, Fluehmann B, Born W, Fischer JA, Muff R. (1997)
Coexistence of novel amylin-binding sites with calcitonin receptors in human breast carcinoma MCF-7 cells.
J Endocrinol, 155 (3): 423-31. [PMID:9487987]