Synonyms: Hycamtin® | SK-S-104864-A
topotecan is an approved drug (EMA and FDA (1996))
Compound class:
Synthetic organic
Comment: Topotecan is a semisynthetic analogue of the natural plant alkaloid camptothecin (PubChem CID 24360). Camptothecin was first isolated from the bark and stem of Camptotheca acuminata, the Chinsese happy tree. Topotecan is an anticancer drug which causes DNA strand breaks and leads to cell-cycle arrest and cell death.
Marketed formulations may contain topotecan hydrochloride (PubChem CID 60699). Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: topotecan |
|
Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (EMA and FDA (1996)) |
International Nonproprietary Names | |
INN number | INN |
6783 | topotecan |
Synonyms |
Hycamtin® | SK-S-104864-A |
Database Links | |
CAS Registry No. | 123948-87-8 |
ChEBI | CHEBI:63632 |
ChEMBL Ligand | CHEMBL84 |
DrugBank Ligand | DB01030 |
DrugCentral Ligand | 2707 |
GtoPdb PubChem SID | 178103679 |
PubChem CID | 60700 |
RCSB PDB Ligand | TTC |
Search Google for chemical match using the InChIKey | UCFGDBYHRUNTLO-QHCPKHFHSA-N |
Search Google for chemicals with the same backbone | UCFGDBYHRUNTLO |
Search PubMed clinical trials | topotecan |
Search PubMed titles | topotecan |
Search PubMed titles/abstracts | topotecan |
UniChem Compound Search for chemical match using the InChIKey | UCFGDBYHRUNTLO-QHCPKHFHSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | UCFGDBYHRUNTLO-QHCPKHFHSA-N |
Wikipedia | topotecan |