Nuclear hormone receptors

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0B. DAX-like receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
0B. DAX-like receptors NR0B1 DAX1 NR0B1
Nr0b1
Nr0b1
Orphan
0B. DAX-like receptors NR0B2 SHP NR0B2
Nr0b2
Nr0b2
Orphan
1A. Thyroid hormone receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
1A. Thyroid hormone receptors T4
triiodothyronine
NR1A1 Thyroid hormone receptor-α THRA
Thra
Thra
Triiodothyronine is the more potent endogenous ligand
1A. Thyroid hormone receptors T4
triiodothyronine
NR1A2 Thyroid hormone receptor-β THRB
Thrb
Thrb
Triiodothyronine is the more potent endogenous ligand
1B. Retinoic acid receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
1B. Retinoic acid receptors tretinoin
NR1B1 Retinoic acid receptor-α RARA
Rara
Rara
1B. Retinoic acid receptors tretinoin
NR1B2 Retinoic acid receptor-β RARB
Rarb
Rarb
1B. Retinoic acid receptors tretinoin
NR1B3 Retinoic acid receptor-γ RARG
Rarg
Rarg
1C. Peroxisome proliferator-activated receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
1C. Peroxisome proliferator-activated receptors NR1C1 Peroxisome proliferator-activated receptor-α PPARA
Ppara
Ppara
LTB4, fatty acids and eisosanoids are natural ligands
1C. Peroxisome proliferator-activated receptors NR1C2 Peroxisome proliferator-activated receptor-β/δ PPARD
Ppard
Ppard
Fatty acids and eisosanoids are natural ligands
1C. Peroxisome proliferator-activated receptors NR1C3 Peroxisome proliferator-activated receptor-γ PPARG
Pparg
Pparg
Fatty acids, prostaglandin J2 and eisosanoids are reported natural ligands
1D. Rev-Erb receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
1D. Rev-Erb receptors NR1D1 Rev-Erb-α NR1D1
Nr1d1
Nr1d1
Orphan
1D. Rev-Erb receptors NR1D2 Rev-Erb-β NR1D2
Nr1d2
Nr1d2
Orphan
1F. Retinoic acid-related orphans
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
1F. Retinoic acid-related orphans NR1F1 RAR-related orphan receptor-α RORA
Rora
Rora
1F. Retinoic acid-related orphans NR1F2 RAR-related orphan receptor-β RORB
Rorb
Rorb
1F. Retinoic acid-related orphans NR1F3 RAR-related orphan receptor-γ RORC
Rorc
Rorc
Orphan
1H. Liver X receptor-like receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
1H. Liver X receptor-like receptors NR1H4 Farnesoid X receptor NR1H4
Nr1h4
Nr1h4
A series of bile acids are natural ligands
1H. Liver X receptor-like receptors NR1H5 Farnesoid X receptor-β NR1H5P
Nr1h5
Nr1h5
A series of oxysterols and bile acids are natural ligands
1H. Liver X receptor-like receptors NR1H3 Liver X receptor-α NR1H3
Nr1h3
Nr1h3
A series of oxysterols are natural ligands
1H. Liver X receptor-like receptors NR1H2 Liver X receptor-β NR1H2
Nr1h2
Nr1h2
A series of oxysterols are natural ligands
1I. Vitamin D receptor-like receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
1I. Vitamin D receptor-like receptors 1,25-dihydroxyvitamin D3
NR1I1 Vitamin D receptor VDR
Vdr
Vdr
1I. Vitamin D receptor-like receptors NR1I2 Pregnane X receptor NR1I2
Nr1i2
Nr1i2
Xenobiotics, steroids and benzoates have been proposed as the natural ligands
1I. Vitamin D receptor-like receptors NR1I3 Constitutive androstane receptor NR1I3
Nr1i3
Nr1i3
Xenobiotics and androstanes have been proposed as the natural ligands
2A. Hepatocyte nuclear factor-4 receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
2A. Hepatocyte nuclear factor-4 receptors NR2A1 Hepatocyte nuclear factor-4-α HNF4A
Hnf4a
Hnf4a
Orphan
2A. Hepatocyte nuclear factor-4 receptors NR2A2 Hepatocyte nuclear factor-4-γ HNF4G
Hnf4g
Hnf4g
Orphan
2B. Retinoid X receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
2B. Retinoid X receptors alitretinoin
NR2B1 Retinoid X receptor-α RXRA
Rxra
Rxra
2B. Retinoid X receptors alitretinoin
NR2B2 Retinoid X receptor-β RXRB
Rxrb
Rxrb
2B. Retinoid X receptors alitretinoin
NR2B3 Retinoid X receptor-γ RXRG
Rxrg
Rxrg
2C. Testicular receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
2C. Testicular receptors NR2C1 Testicular receptor 2 NR2C1
Nr2c1
Nr2c1
Orphan
2C. Testicular receptors NR2C2 Testicular receptor 4 NR2C2
Nr2c2
Nr2c2
Orphan
2E. Tailless-like receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
2E. Tailless-like receptors NR2E1 TLX NR2E1
Nr2e1
Nr2e1
Orphan
2E. Tailless-like receptors NR2E3 PNR NR2E3
Nr2e3
Orphan
2F. COUP-TF-like receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
2F. COUP-TF-like receptors NR2F1 COUP-TF1 NR2F1
Nr2f1
Nr2f1
Orphan
2F. COUP-TF-like receptors NR2F2 COUP-TF2 NR2F2
Nr2f2
Nr2f2
Orphan
2F. COUP-TF-like receptors NR2F6 V-erbA-related gene NR2F6
Nr2f6
Nr2f6
Orphan
3A. Estrogen receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
3A. Estrogen receptors 17β-estradiol
NR3A1 Estrogen receptor-α ESR1
Esr1
Esr1
3A. Estrogen receptors 17β-estradiol
NR3A2 Estrogen receptor-β ESR2
Esr2
Esr2
3B. Estrogen-related receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
3B. Estrogen-related receptors NR3B1 Estrogen-related receptor-α ESRRA
Esrra
Esrra
Orphan
3B. Estrogen-related receptors NR3B2 Estrogen-related receptor-β ESRRB
Esrrb
Esrrb
Orphan
3B. Estrogen-related receptors NR3B3 Estrogen-related receptor-γ ESRRG
Esrrg
Esrrg
Orphan
3C. 3-Ketosteroid receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
3C. 3-Ketosteroid receptors dihydrotestosterone
testosterone
NR3C4 Androgen receptor AR
Ar
Ar
Dihydrotestosterone has greater potency than testosterone
3C. 3-Ketosteroid receptors aldosterone
corticosterone
cortisol
deoxycortisone
NR3C1 Glucocorticoid receptor NR3C1
Nr3c1
Nr3c1
Cortisol and corticosterone are the principal endogenous agonists
3C. 3-Ketosteroid receptors aldosterone
corticosterone
cortisol
progesterone
NR3C2 Mineralocorticoid receptor NR3C2
Nr3c2
Nr3c2
3C. 3-Ketosteroid receptors progesterone
NR3C3 Progesterone receptor PGR
Pgr
Pgr
4A. Nerve growth factor IB-like receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
4A. Nerve growth factor IB-like receptors NR4A1 Nerve Growth factor IB NR4A1
Nr4a1
Nr4a1
Orphan
4A. Nerve growth factor IB-like receptors NR4A2 Nuclear receptor related 1 NR4A2
Nr4a2
Nr4a2
Orphan
4A. Nerve growth factor IB-like receptors NR4A3 Neuron-derived orphan receptor 1 NR4A3
Nr4a3
Nr4a3
Orphan
5A. Fushi tarazu F1-like receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
5A. Fushi tarazu F1-like receptors NR5A1 Steroidogenic factor 1 NR5A1
Nr5a1
Nr5a1
Orphan
5A. Fushi tarazu F1-like receptors NR5A2 Liver receptor homolog-1 NR5A2
Nr5a2
Nr5a2
Orphan
6A. Germ cell nuclear factor receptors
Family name Ligand Receptor nomenclature Receptor common name Human gene symbol Rat gene symbol Mouse gene symbol Comment
6A. Germ cell nuclear factor receptors NR6A1 Germ cell nuclear factor NR6A1
Nr6a1
Nr6a1
Orphan