Cathepsin A

Target id: 1581

Nomenclature: Cathepsin A

Family: S10: Carboxypeptidase Y

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Cathepsin A in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 480 20q13.12 CTSA cathepsin A
Mouse - 474 2 H3 Ctsa cathepsin A
Rat - 456 3q42 Ctsa cathepsin A
Previous and Unofficial Names
carboxypeptidase C | GSL | PPGB | carboxypeptidase Y-like kininase | carboxypeptidase-L | deamidase | lysosomal carboxypeptidase A | lysosomal protective protein | urinary kininase | protective protein for beta-galactosidase | PPCA
Database Links
Specialist databases
MEROPS S10.002 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.16.5

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 8a [PMID: 22861813] Hs Inhibition 7.4 pIC50 4
pIC50 7.4 (IC50 3.8x10-8 M) [4]
example 166 [WO2014154727] Hs Inhibition 7.0 pIC50 3
pIC50 7.0 (IC50 9.2x10-8 M) [3]
telaprevir Hs Inhibition 7.0 pIC50 2
pIC50 7.0 (IC50 1x10-7 M) [2]
boceprevir Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Galactosialidosis
OMIM: 256540
Orphanet: ORPHA351

References

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1. Ruf S et al.. (2013) Use of boceprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases. Patent number: WO2013072327. Assignee: Sanofi. Priority date: 14/11/2011. Publication date: 23/05/2013.

2. Ruf S et al. (2013) Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases. Patent number: WO2013072328. Assignee: Sanofi. Priority date: 14/11/2011. Publication date: 23/05/2013.

3. Ruf S et al. (2014) Biaryl-propionic acid derivatives and their use as pharmaceuticals. Patent number: WO2014154727. Assignee: Sanofi. Priority date: 20/03/2013. Publication date: 02/10/2014.

4. Ruf S, Buning C, Schreuder H, Horstick G, Linz W, Olpp T, Pernerstorfer J, Hiss K, Kroll K, Kannt A et al.. (2012) Novel β-amino acid derivatives as inhibitors of cathepsin A. J. Med. Chem., 55 (17): 7636-49. [PMID:22861813]

How to cite this page

S10: Carboxypeptidase Y: Cathepsin A. Last modified on 05/11/2014. Accessed on 20/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1581.