butyrophilin subfamily 3 member A1 | Butyrophilin and butyrophilin-like proteins | IUPHAR/BPS Guide to PHARMACOLOGY

butyrophilin subfamily 3 member A1

Target id: 2948

Nomenclature: butyrophilin subfamily 3 member A1

Family: Butyrophilin and butyrophilin-like proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for butyrophilin subfamily 3 member A1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 513 6p22.2 BTN3A1 butyrophilin subfamily 3 member A1
Gene and Protein Information Comments
Several transcript variants and protein isoforms are predicted from the human gene. We provide details for the longest form (variant 1, isoform a) here.
Previous and Unofficial Names
BT3.1 | BTN3.1 | CD277
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
POM2-C-HMBP Hs Binding - - 1
Physiological Functions
The γδ T cell subset expressing the T cell receptor Vγ2Vδ2, are activated by isoprenoid metabolites, such as (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP- a foreign microbial antigen) and isopentenyl pyrophosphate (IPP- a self-metabolite). Activation appears to be mediated by binding to an intracellular domain of the BTN3A1 protein. Using this mechanism, BTN3A1 functions as a sensor for intracellular isoprenoid metabolism to signal changes to Vγ2Vδ2 T cells.
Species:  Human
Tissue:  γδ T cells
References:  4


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1. Kilcollins AM, Li J, Hsiao CH, Wiemer AJ. (2016) HMBPP Analog Prodrugs Bypass Energy-Dependent Uptake To Promote Efficient BTN3A1-Mediated Malignant Cell Lysis by Vγ9Vδ2 T Lymphocyte Effectors. J. Immunol., 197 (2): 419-28. [PMID:27271567]

2. Morita CT, Jin C, Sarikonda G, Wang H. (2007) Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol. Rev., 215: 59-76. [PMID:17291279]

3. Moulin M, Alguacil J, Gu S, Mehtougui A, Adams EJ, Peyrottes S, Champagne E. (2017) Vγ9Vδ2 T cell activation by strongly agonistic nucleotidic phosphoantigens. Cell. Mol. Life Sci., 74 (23): 4353-4367. [PMID:28669030]

4. Wang H, Morita CT. (2015) Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells. J. Immunol., 195 (10): 4583-94. [PMID:26475929]

5. Zocchi MR, Costa D, Venè R, Tosetti F, Ferrari N, Minghelli S, Benelli R, Scabini S, Romairone E, Catellani S et al.. (2017) Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity. Oncoimmunology, 6 (3): e1278099. [PMID:28405500]

How to cite this page

Butyrophilin and butyrophilin-like proteins: butyrophilin subfamily 3 member A1. Last modified on 01/08/2017. Accessed on 21/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2948.