FP receptor

Target id: 344

Nomenclature: FP receptor

Family: Prostanoid receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for FP receptor in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 386 1p31.1 PTGFR prostaglandin F receptor 2,4,23
Mouse 7 366 3 H3 Ptgfr prostaglandin F receptor 14,44
Rat 7 366 2q45 Ptgfr prostaglandin F receptor 21,23
Previous and Unofficial Names
PF2AR | PGF receptor | PGF2 alpha receptor | prostaglandin F receptor | prostaglandin F2-alpha receptor | prostaglandin F receptor (FP)
Database Links
Specialist databases
GPCRDB pf2r_human (Hs), pf2r_mouse (Mm), pf2r_rat (Rn)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
PGD2
PGE2
PGF
PGI2
Comments: PGF is the principal endogenous agonist
Potency order of endogenous ligands
PGF > PGD2 > PGE2 > PGI2, thromboxane A2

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]PGF Mm Full agonist 8.9 pKd 44
pKd 8.9 [44]
[3H]PGF Hs Full agonist 8.1 – 9.0 pKd 1-2,53
pKd 8.1 – 9.0 (Kd 7.9x10-9 – 1x10-9 M) [1-2,53]
cloprostenol Hs Full agonist 9.3 pKi 1
pKi 9.3 [1]
fluprostenol Hs Full agonist 8.6 pKi 1
pKi 8.6 [1]
latanoprost (free acid form) Hs Full agonist 8.6 pKi 1
pKi 8.6 [1]
latanoprostene bunod Hs Agonist ~8.6 pKi 1,22
pKi ~8.6 (Ki ~2.51x10-9 M) [1,22]
Description: Value based on agonist activity of latanoprost.
PGF Mm Full agonist 8.5 pKi 20
pKi 8.5 [20]
fluprostenol Mm Full agonist 8.4 pKi 20
pKi 8.4 [20]
PGF Hs Full agonist 7.9 – 8.5 pKi 1,31,53
pKi 7.9 – 8.5 [1,31,53]
PGD2 Hs Full agonist 7.7 pKi 31
pKi 7.7 [31]
PGD2 Mm Full agonist 7.3 pKi 20
pKi 7.3 [20]
enprostil Hs Full agonist 7.1 pKi 1
pKi 7.1 [1]
PGE2 Mm Full agonist 7.0 pKi 20
pKi 7.0 [20]
I-BOP Mm Full agonist 7.0 pKi 20
pKi 7.0 [20]
MB-28767 Mm Full agonist 6.9 pKi 20
pKi 6.9 [20]
sulprostone Hs Full agonist 6.7 pKi 1
pKi 6.7 [1]
PGE2 Hs Full agonist 6.4 – 6.9 pKi 1,31
pKi 6.4 – 6.9 [1,31]
U46619 Hs Full agonist 6.6 pKi 1
pKi 6.6 [1]
carbacyclin Hs Full agonist 6.4 – 6.5 pKi 1
pKi 6.4 – 6.5 [1]
MB-28767 Hs Full agonist 6.3 pKi 1
pKi 6.3 [1]
latanoprost (isopropyl ester) Hs Full agonist 6.3 pKi 1
pKi 6.3 [1]
iloprost Hs Full agonist 6.2 pKi 1
pKi 6.2 [1]
U46619 Mm Full agonist 6.0 pKi 20
pKi 6.0 [20]
carbacyclin Mm Full agonist 5.9 pKi 20
pKi 5.9 [20]
L-888,607 Hs Full agonist 5.0 pKi 12
pKi 5.0 [12]
tafluprost acid Hs Agonist 9.3 pEC50 47
pEC50 9.3 (EC50 5.3x10-10 M) [47]
Description: Affinity measured in a cell line stably expressing the recombinant human prostanoid FP receptor.
AL12180 Hs Agonist 7.7 – 7.9 pEC50 41
pEC50 7.7 – 7.9 (EC50 2.2x10-8 – 1.4x10-8 M) [41]
AL-8810 Mm Partial agonist 6.7 pEC50 13
pEC50 6.7 [13]
AL-8810 Rn Partial agonist 6.7 pEC50 13
pEC50 6.7 [13]
13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF Hs Full agonist 8.6 – 9.0 pIC50 52
pIC50 8.6 – 9.0 [52]
bimatoprost (free acid form) Hs Full agonist 8.7 pIC50 55
pIC50 8.7 [55]
bimatoprost Hs Full agonist 5.3 pIC50 56
pIC50 5.3 (IC50 5.011x10-6 M) [56]
tafluprost Hs Agonist - - 47
[47]
View species-specific agonist tables
Agonist Comments
Fluprostenol is a widely used selective FP receptor agonist [16-17]. Latanoprost free acid is a suitable substitute.
AGN-204396 blocks the contractile action of PGF-1-ethanolamide, but not PGF, on cat iris sphincter muscle, indicating the presence of "prostamide receptors".
The free acid form of AL-12182, AL-12180, used in in vitro studies, has a EC50 value of 15nM which is the concentration of the compound giving half-maximal stimulation of IP turnover in HEK-293 cells expressing the human FP receptor [41].
Tafluprost: the FP receptor is tagged as the primary drug target for tafluprost, but note that this is a prodrug and actual activity is attributable to the active metabolite tafluprost acid.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AS604872 Hs Antagonist 7.5 pKi 6
pKi 7.5 (Ki 3.5x10-8 M) [6]
Antagonist Comments
True antagonists for the FP receptor are not available. AL-8810 (11S,15R-11-fluoro-w-pentanor-16-(2-indanyl)-PGF), a selective FP partial agonist, has been used to block FP receptors [13].
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  5,15
Secondary Transduction Mechanisms
Transducer Effector/Response
Gs family
References: 
Tissue Distribution
Eye: endothelial and smooth muscle cells of blood vessels of the iris, ciliary body and choroid. Ciliary muscle (circular muscle, collagenous connective tissues).
Species:  Human
Technique:  in situ hybridisation.
References:  28,58
Myometrium.
Species:  Human
Technique:  Northern blotting.
References:  24
Eye: sclera.
Species:  Human
Technique:  Immunocytochemistry and RT-PCR.
References:  3
Kidney (distal tubules), uterus, ovary, testes, skin, liver.
Species:  Mouse
Technique:  In situ hybridisation and β-galactosidase staining.
References:  39
Luteal cells of corpus luteum > kidney, heart, stomach, lung.
Species:  Mouse
Technique:  Northern blotting.
References:  44
Ovary.
Species:  Mouse
Technique:  RT-PCR.
References:  33
Normal, hyperplastic and neoplastic skin.
Species:  Mouse
Technique:  RT-PCR and Northern Blotting.
References:  29
Ovary.
Species:  Rat
Technique:  Immunohistochemistry.
References:  34
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of Ca2+ levels in Xenopus oocytes transfected with the FP receptor using electrophysiology (measurement of Ca2+-dependent Cl- current) and an aequorin luminescence assay.
Species:  Human
Tissue:  Xenopus oocytes.
Response measured:  Increase in Ca2+ concentration.
References:  2
Measurement of Ca2+ levels in HEK 293 cells transfected with the human FP receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Ca2+ mobilisation.
References:  18
Measurement of Ca2+ levels in rat A7r5 cells endogenously expressing the FP receptor.
Species:  Rat
Tissue:  A7r5 cells.
Response measured:  Ca2+ mobilisation.
References:  18
Measurement of Ca2+ levels in mouse Swiss 3T3 cells endogenously expressing the FP receptor.
Species:  Mouse
Tissue:  Swiss 3T3 cells.
Response measured:  Ca2+ mobilisation.
References:  18,54,57
Measurement of phosphoinositide (PI) levels in LLC-PK1 cells transfected with the rat FP receptor.
Species:  Human
Tissue:  LLC-PK1 cells.
Response measured:  Stimulation of PI hydrolysis.
References:  21
Measurement of PLC activity, Ca2+ levels and [3H]thymidine incorporation in mouse fibroblast NIH 3T3 cells endogenously expressing the FP receptor.
Species:  Mouse
Tissue:  NIH 3T3 cells.
Response measured:  Stimulation of PLC activity, Ca2+ mobilisation and and increase in [3H]thymidine incorporation.
References:  30
Measurement of PLC activity and Ca2+ levels in human granulosa cells endogenously expressing the FP receptor.
Species:  Human
Tissue:  Granulosa cells.
Response measured:  Stimulation of PLCβ activity and an increase in Ca2+.
References:  5
Measurement of IP3 levels in COS cells transfected with the mouse FP receptor.
Species:  Mouse
Tissue:  COS cells.
Response measured:  Stimulation of IP3 accumulation.
References:  44
Determination of PLC activity and Ca2+ mobilisation by electrophysiological measurement of inward current.
Species:  Mouse
Tissue:  Xenopus oocytes.
Response measured:  Stimulation of PLC activity and Ca2+ mobilisation.
References:  44
Physiological Functions
Increase force of contraction of cardiac muscle.
Species:  Rat
Tissue:  Left ventricular strips.
References:  38
Luteolysis.
Species:  Mouse
Tissue:  In vivo (ovary).
References:  46
Contraction.
Species:  Mouse
Tissue:  Myometrium.
References:  36
Contraction.
Species:  Human
Tissue:  Myometrium.
References:  10
Decrease in intraocular pressure.
Species:  Mouse
Tissue:  In vivo (eye).
References:  35
Inhibition of prolactin receptor expression in the corpus luteum.
Species:  Rat
Tissue:  In vivo (corpus luteum).
References:  43
Physiological Consequences of Altering Gene Expression
FP receptor knockout mice exhibit increased apoptosis in the placenta.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  25-27
FP receptor knockout mice to not exhibit the lowering of intraocular pressure induced by prostaglandin analogues, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  7-8,35
FP receptor knockout mice exhibit decreased aquaporin-8 expression in fetal membranes, which may affect amniotic fluid volume.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  42
FP receptor knockout mice displayed impaired inflammatory tachycardia.
Species:  Human
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  48
FP receptor knockout mice exhibit inhibition of cytokine-induced increase in beating rate, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  48
FP receptor knockout mice fail to exhibit luteolysis and hence initiate parturition, and there is no induction of oxytocin receptors in the uterus. Although FP receptor knockout mice cannot deliver fetuses to term, they can be rescued by caesarean section.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  9,19,45-46,49-50
FP receptor knockout mice exhibit reduced responses in bleomycin-induced pulmonary fibrosis.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  32
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ptgfrtm1Aic Ptgfrtm1Aic/Ptgfrtm1Aic
involves: 129P2/OlaHsd * C57BL/6
MGI:97796  MP:0002783 abnormal ovarian secretion PMID: 9235889 
Ptgfrtm1Aic Ptgfrtm1Aic/Ptgfrtm1Aic
involves: 129P2/OlaHsd * C57BL/6
MGI:97796  MP:0002907 abnormal parturition PMID: 12606450  9235889 
Ptgfrtm1Aic Ptgfrtm1Aic/Ptgfrtm1Aic
involves: 129P2/OlaHsd * C57BL/6
MGI:97796  MP:0001919 abnormal reproductive system physiology PMID: 9235889 
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  The first splice variant of the human FP receptor has been cloned from the heart and placenta and named FPS. It lacks TM 7 and the c-terminal, although the consequences of this are at present unknown.
References:  51
General Comments
An alternatively spliced C-terminal form of the ovine FP receptor, FPB (318aa), has been described [37,37,40]. Unlike FPA, FPB is resistant to PKC-dependent phosphorylation [11]. There is no clear evidence for FP receptor subtypes.

References

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1. Abramovitz M, Adam M, Boie Y, Carriere M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM. (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogues. Biochim. Biophys. Acta.1483: 285-293. [PMID:10634944]

2. Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R. (1994) Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem269: 2632-2636. [PMID:8300593]

3. Anthony TL, Lindsey JD, Aihara M, Weinreb RN. (2001) Detection of prostaglandin EP(1), EP(2), and FP receptor subtypes in human sclera. Invest Ophthalmol Vis Sci42: 3182-3186. [PMID:11726620]

4. Betz R, Lagercrantz J, Kedra D, Dumanski JP, Nordenskjöld A. (1999) Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene. Biochem Biophys Res Commun254: 413-416. [PMID:9918852]

5. Carrasco MP, Asbóth G, Phaneuf S, López Bernal A. (1997) Activation of the prostaglandin FP receptor in human granulosa cells. J Reprod Fertil111: 309-317. [PMID:9462300]

6. Cirillo R, Tos EG, Page P, Missotten M, Quattropani A, Scheer A, Schwarz MK, Chollet A. (2007) Arrest of preterm labor in rat and mouse by an oral and selective nonprostanoid antagonist of the prostaglandin F2alpha receptor (FP). Am. J. Obstet. Gynecol.197 (1): 54.e1-9. [PMID:17618756]

7. Crowston JG, Lindsey JD, Aihara M, Weinreb RN. (2004) Effect of latanoprost on intraocular pressure in mice lacking the prostaglandin FP receptor. Invest Ophthalmol Vis Sci45: 3555-3559. [PMID:15452062]

8. Crowston JG, Lindsey JD, Morris CA, Wheeler L, Medeiros FA, Weinreb RN. (2005) Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. Invest Ophthalmol Vis Sci46: 4571-4577. [PMID:16303950]

9. Croy BA, Chantakru S, Narumiya S, Ichikawa A, Sugimoto Y. (2000) Prolonged gestation does not extend survival of uterine natural killer lymphocytes in mice deleted in the receptor for prostaglandin F2alpha. J Reprod Immunol.46: 125-129. [PMID:10706943]

10. Friel AM, O'Reilly MW, Sexton DJ, Morrison JJ. (2005) Specific PGF(2alpha) receptor (FP) antagonism and human uterine contractility in vitro. BJOG112: 1034-1042. [PMID:16045514]

11. Fujino H, Srinivasan D, Pierce KL, Regan JW. (2000) Differential regulation of prostaglandin F receptor isoforms by protein kinase C. Mol. Pharmacol.57: 353-358. [PMID:10648645]

12. Gervais FG, Morello JP, Beaulieu C, Sawyer N, Denis D, Greig G, Malebranche AD, O'Neill GP. (2005) Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol Pharmacol67: 1834-1839. [PMID:15755909]

13. Griffin BW, Klimko P, Crider JY, Sharif NA. (1999) AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther290: 1278-1284. [PMID:10454504]

14. Ishikawa TO, Tamai Y, Rochelle JM, Hirata M, Namba T, Sugimoto Y, Ichikawa A, Narumiya S, Taketo MM, Seldin MF. (1996) Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. Genomics32: 285-288. [PMID:8833158]

15. Ito S, Sakamoto K, Mochizuki-Oda N, Ezashi T, Miwa K, Okuda-Ashitaka E, Shevchenko VI, Kiso Y, Hayaishi O. (1994) Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells. Biochem Biophys Res Commun200: 756-762. [PMID:8179609]

16. Jones RL, Marr CG. (1977) Actions of 16-aryloxy analogues of prostaglandin F2alpha on preparations responsive to prostaglandin endoperoxides. Br J Pharmacol61: 694-696. [PMID:597671]

17. Jones RL, Peesapati V, Wilson NH. (1982) Antagonism of the thromboxane-sensitive contractile systems of the rabbit aorta, dog saphenous vein and guinea-pig trachea. Br J Pharmacol76: 423-438. [PMID:6286023]

18. Kelly CR, Williams GW, Sharif NA. (2003) Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors. J Pharmacol Exp Ther304: 238-245. [PMID:12490597]

19. Kimura T, Ogita K, Kusui C, Ohashi K, Azuma C, Murata Y. (1999) What knockout mice can tell us about parturition. Rev Reprod4: 73-80. [PMID:10357094]

20. Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S. (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol.122: 217-224. [PMID:9313928]

21. Kitanaka J, Hasimoto H, Sugimoto Y, Negishi M, Aino H, Gotoh M, Ichikawa A, Baba A. (1994) Cloning and expression of a cDNA for rat prostaglandin F2a receptor. Prostaglandins48: 31-41. [PMID:7972878]

22. Krauss AH, Impagnatiello F, Toris CB, Gale DC, Prasanna G, Borghi V, Chiroli V, Chong WK, Carreiro ST, Ongini E. (2011) Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models. Exp. Eye Res.93 (3): 250-5. [PMID:21396362]

23. Lake S, Gullberg H, Wahlqvist J, Sjögren AM, Kinhult A, Lind P, Hellström-Lindahl E, Stjernschantz J. (1994) Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS Lett.355 (3): 317-25. [PMID:7988697]

24. Matsumoto T, Sagawa N, Yoshida M, Mori T, Tanaka I, Mukoyama M, Kotani M, Nakao K. (1997) The prostaglandin E2 and F2 alpha receptor genes are expressed in human myometrium and are down-regulated during pregnancy. Biochem Biophys Res Commun238: 838-841. [PMID:9325177]

25. Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Fujii E, Hosono T, Murata Y, Sugimoto Y, Ichikawa A. (2002) Apoptosis and related proteins during parturition in prostaglandin F receptor-deficient mice. Biochem Biophys Res Commun292: 675-681. [PMID:11922619]

26. Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Shioji M, Murata Y, Sugimoto Y, Ichikawa A. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol Reprod68: 1968-1974. [PMID:12606450]

27. Mu J, Kanzaki T, Tomimatsu T, Fukuda H, Wasada K, Fujii E, Endoh M, Kozuki M, Murata Y, Sugimoto Y, Ichikawa A. (2003) Expression of apoptosis in placentae from mice lacking the prostaglandin F receptor. Placenta23: 215-223. [PMID:11945089]

28. Mukhopadhyay P, Bian L, Yin H, Bhattacherjee P, Paterson C. (2001) Localization of EP(1) and FP receptors in human ocular tissues by in situ hybridization. Invest Ophthalmol Vis Sci42: 424-428. [PMID:11157877]

29. Müller K, Krieg P, Marks F, Fürstenberger G. (2000) Expression of PGF(2alpha) receptor mRNA in normal, hyperplastic and neoplastic skin. Carcinogenesis21: 1063-1066. [PMID:10783334]

30. Nakao A, Watanabe T, Taniguchi S, Nakamura M, Honda Z, Shimizu T, Kurokawa K. (1993) Characterization of prostaglandin F2 alpha receptor of mouse 3T3 fibroblasts and its functional expression in Xenopus laevis oocytes. J Cell Physiol155: 257-264. [PMID:8482718]

31. Neuschäfer-Rube F, Engemaier E, Koch S, Böer U, Püschel GP. (2003) Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J371: 443-449. [PMID:12519077]

32. Oga T, Matsuoka T, Yao C, Nonomura K, Kitaoka S, Sakata D, Kita Y, Tanizawa K, Taguchi Y, Chin K et al.. (2009) Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta. Nat. Med.15 (12): 1426-30. [PMID:19966781]

33. Olofsson JI, Leung CH, Bjurulf E, Ohno T, Selstam G, Peng C, Leung PC. (1996) Characterization and regulation of a mRNA encoding the prostaglandin F2alpha receptor in the rat ovary. Mol Cell Endocrinol123: 45-52. [PMID:8912810]

34. Orlicky DJ, Fisher L, Dunscomb N, Miller GJ. (1992) Immunohistochemical localization of PGF2 alpha receptor in the rat ovary. Prostaglandins Leukot Essent Fatty Acids46: 223-229. [PMID:1508956]

35. Ota T, Aihara M, Narumiya S, Araie M. (2005) The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. Invest Ophthalmol Vis Sci46: 4159-4163. [PMID:16249494]

36. Peri KG, Quiniou C, Hou X, Abran D, Varma DR, Lubell WD, Chemtob S. (2002) THG113: a novel selective FP antagonist that delays preterm labor. Semin Perinatol26: 389-397. [PMID:12537309]

37. Pierce KL, Bailey TJ, Hoyer PB, Gil DW, Woodward DF, Regan JW. (1997) Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor. J. Biol. Chem.272: 883-887. [PMID:8995377]

38. Pönicke K, Giessler C, Grapow M, Heinroth-Hoffmann I, Becker K, Osten B, Brodde OE. (2000) FP-receptor mediated trophic effects of prostanoids in rat ventricular cardiomyocytes. Br J Pharmacol129: 1723-1731. [PMID:10780979]

39. Saito O, Guan Y, Qi Z, Davis LS, Kömhoff M, Sugimoto Y, Narumiya S, Breyer RM, Breyer MD. (2003) Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract. Am J Physiol Renal Physiol284: F1164-F1170. [PMID:12631554]

40. Sakamoto K, Ezashi T, Miwa K, Okuda-Ashitaka E, Houtani T, Sugimoto T, Ito S, Hayaishi O. (1994) Molecular cloning and expression of a cDNA of the bovine prostaglandin F2a receptor. J. Biol. Chem.269: 3881-3886. [PMID:7508922]

41. Sharif NA, McLaughlin MA, Kelly CR, Xu S, Crider JY, Williams GW, Parker JL. (2006) Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog. J Ocul Pharmacol Ther22 (5): 291-309. [PMID:17076623]

42. Shioji M, Fukuda H, Kanzaki T, Wasada K, Kanagawa T, Shimoya K, Mu J, Sugimoto Y, Murata Y. (2006) Reduction of aquaporin-8 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2alpha receptor. J Obstet Gynaecol Res32: 373-378. [PMID:16882262]

43. Stocco C, Djiane J, Gibori G. (2003) Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum. Endocrinology144: 3301-3305. [PMID:12865306]

44. Sugimoto Y, Hasumoto K, Namba T, Irie A, Katsuyama M, Negishi M, Kakizuka A, Narumiya S, Ichikawa A. (1994) Cloning and expression of a cDNA for mouse prostglandin F receptor. J. Biol. Chem.269: 1356-1360. [PMID:8288601]

45. Sugimoto Y, Segi E, Tsuboi K, Ichikawa A, Narumiya S. (1998) Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition. Adv Exp Med Biol449: 317-321. [PMID:10026819]

46. Sugimoto Y, Yamasaki A, Segi E, Tsuboi K, Aze Y, Nishimura T, Oida H, Yoshida N, Tanaka T, Katsuyama M, Hasumoto K, Murata T, Hirata M, Ushikubi F, Negishi M, Ichikawa A, Narumiya S. (1997) Failure of parturition in mice lacking the prostaglandin F receptor. Science277: 681-683. [PMID:9235889]

47. Takagi Y, Nakajima T, Shimazaki A, Kageyama M, Matsugi T, Matsumura Y, Gabelt BT, Kaufman PL, Hara H. (2004) Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp. Eye Res.78 (4): 767-76. [PMID:15037111]

48. Takayama K, Yuhki K, Ono K, Fujino T, Hara A, Yamada T, Kuriyama S, Karibe H, Okada Y, Takahata O, Taniguchi T, Iijima T, Iwasaki H, Narumiya S, Ushikubi F. (2005) Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med11: 562-566. [PMID:15834430]

49. Tsuboi K, Iwane A, Nakazawa S, Sugimoto Y, Ichikawa A. (2003) Role of prostaglandin H2 synthase 2 in murine parturition: study on ovariectomy-induced parturition in prostaglandin F receptor-deficient mice. Biol Reprod69: 195-201. [PMID:12620936]

50. Tsuboi K, Sugimoto Y, Iwane A, Yamamoto K, Yamamoto S, Ichikawa A. (2000) Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice. Endocrinology141: 315-324. [PMID:10614653]

51. Vielhauer GA, Fujino H, Regan JW. (2004) Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. Arch Biochem Biophys421: 175-185. [PMID:14984197]

52. Wang Y, Wos JA, Dirr MJ, Soper DL, deLong MA, Mieling GE, De B, Amburgey JS, Suchanek EG, Taylor CJ. (2000) Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor. J Med Chem43: 945-952. [PMID:10715159]

53. Wilson RJ, Giblin GM, Roomans S, Rhodes SA, Cartwright KA, Shield VJ, Brown J, Wise A, Chowdhury J, Pritchard S, Coote J, Noel LS, Kenakin T, Burns-Kurtis CL, Morrison V, Gray DW, Giles H. (2006) GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol148: 326-339. [PMID:16604093]

54. Woodward DF, Fairbairn CE, Krauss AH, Lawrence RA, Protzman CE. (1995) Radioligand binding analysis of receptor subtypes in two FP receptor preparations that exhibit different functional rank orders of potency in response to prostaglandins. J. Pharmacol. Exp. Ther.273: 285-287. [PMID:7714778]

55. Woodward DF, Krauss AH, Chen J, Gil DW, Kedzie KM, Protzman CE, Shi L, Chen R, Krauss HA, Bogardus A, Dinh HT, Wheeler LA, Andrews SW, Burk RM, Gac T, Roof MB, Garst ME, Kaplan LJ, Sachs G, Pierce KL, Regan JW, Ross RA, Chan MF. (2000) Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. Br J Pharmacol130: 1933-1943. [PMID:10952685]

56. Woodward DF, Krauss AH, Chen J, Liang Y, Li C, Protzman CE, Bogardus A, Chen R, Kedzie KM, Krauss HA, Gil DW, Kharlamb A, Wheeler LA, Babusis D, Welty D, Tang-Liu DD, Cherukury M, Andrews SW, Burk RM, Garst ME. (2003) Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024). J Pharmacol Exp Ther305: 772-785. [PMID:12606640]

57. Woodward DF, Lawrence RA. (1994) Identification of a single (FP) receptor associated with prostanoid-induced Ca2+ signals in Swiss 3T3 cells. Biochem. Pharmacol.47: 1567-1574. [PMID:8185669]

58. Zhang Z, Yin H. (2002) Detection of EP1 and FP receptor mRNAs in the iris-ciliary body using in situ hybridization. Chin Med J (Engl)115: 1226-1228. [PMID:12215298]

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Xavier Norel, Lucie Clapp, Mark Giembycz, Roy Pettipher, Yukihiko Sugimoto.
Prostanoid receptors: FP receptor. Last modified on 14/08/2017. Accessed on 25/11/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=344.