P2X6

Target id: 483

Nomenclature: P2X6

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for P2X6 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 441 22q11.21 P2RX6 purinergic receptor P2X 6 4
Mouse 2 379 16 A3 P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 3
Rat 2 379 11q23 P2rx6 purinergic receptor P2X 6 1
Previous and Unofficial Names
P2RXL1 | P2XM | P2X purinoceptor 6 | P2X6 receptor | purinergic receptor P2X-like 1 orphan receptor | Rnap2x6 | RNRNAP2X6 | purinergic receptor P2X, ligand-gated ion channel, 6 | purinergic receptor P2X, ligand gated ion channel, 6
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
ATP

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ATP Rn Agonist 6.0 pEC50 2
pEC50 6.0 (EC50 1x10-6 M) [2]

References

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1. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci.16 (8): 2495-507. [PMID:8786426]

2. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J. Med. Chem.45 (19): 4057-93. [PMID:12213051]

3. Nawa G, Urano T, Tokino T, Ochi T, Miyoshi Y. (1998) Cloning and characterization of the murine P2XM receptor gene. J. Hum. Genet.43 (4): 262-7. [PMID:9852680]

4. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T. (1997) Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Res.57 (15): 3281-7. [PMID:9242461]

Contributors

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How to cite this page

Francesco Di Virgilio, Richard J Evans, Simonetta Falzoni, Michael F Jarvis, Charles Kennedy, Brian King, John A. Peters, Baljit S. Khakh, Patrizia Pellegatti.
P2X receptors: P2X6. Last modified on 21/10/2015. Accessed on 24/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=483.