ENaCαβγ

Target id: 742

Nomenclature: ENaCαβγ

Family: Epithelial sodium channel (ENaC)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ENaCαβγ in GtoImmuPdb

Quaternary Structure: Subunits
ENaC α
ENaC β
ENaC γ
Natural/Endogenous Ligands
sodium

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
S3969 Hs - 5.9 pEC50 - no 3
pEC50 5.9 (EC50 1.2x10-6 M) [3]
Not voltage dependent
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
P552-02 Hs - no 8.1 pIC50 - no
pIC50 8.1 (IC50 7.6x10-9 M)
Not voltage dependent
benzamil Hs - no ~8.0 pIC50 - no
pIC50 ~8.0 (IC50 ~1x10-8 M)
Not voltage dependent
amiloride Hs - no 6.7 – 7.0 pIC50 - no
pIC50 6.7 – 7.0 (IC50 2x10-7 – 1x10-7 M)
Not voltage dependent
triamterene Hs - no ~5.3 pIC50 - no 1-2
pIC50 ~5.3 (IC50 ~5x10-6 M) [1-2]
Not voltage dependent

References

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1. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. (1994) Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature367 (6462): 463-7. [PMID:8107805]

2. Kellenberger S, Gautschi I, Schild L. (2003) Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate. Mol. Pharmacol.64 (4): 848-56. [PMID:14500741]

3. Lu M, Echeverri F, Kalabat D, Laita B, Dahan DS, Smith RD, Xu H, Staszewski L, Yamamoto J, Ling J et al.. (2008) Small molecule activator of the human epithelial sodium channel. J. Biol. Chem.283 (18): 11981-94. [PMID:18326490]

Contributors

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How to cite this page

Israel Hanukoglu.
Epithelial sodium channel (ENaC): ENaCαβγ. Last modified on 22/07/2014. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=742.