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GPR25

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Target not currently curated in GtoImmuPdb

Target id: 95

Nomenclature: GPR25

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 361 1q32.1 GPR25 G protein-coupled receptor 25 1
Mouse 7 358 1 E4 Gpr25 G protein-coupled receptor 25
Rat 7 345 13q13 Gpr25 G protein-coupled receptor 25
Database Links Click here for help
Specialist databases
GPCRdb gpr25_human (Hs), gpr25_mouse (Mm)
Other databases
Alphafold O00155 (Hs), P0C5I1 (Mm)
ChEMBL Target CHEMBL4523858 (Hs)
Ensembl Gene ENSG00000170128 (Hs), ENSMUSG00000052759 (Mm), ENSRNOG00000008603 (Rn)
Entrez Gene 2848 (Hs), 383563 (Mm), 363993 (Rn)
Human Protein Atlas ENSG00000170128 (Hs)
KEGG Gene hsa:2848 (Hs), mmu:383563 (Mm), rno:363993 (Rn)
OMIM 602174 (Hs)
Pharos O00155 (Hs)
RefSeq Nucleotide NM_005298 (Hs), NM_001101516 (Mm)
RefSeq Protein NP_005289 (Hs), NP_001094986 (Mm)
UniProtKB O00155 (Hs), P0C5I1 (Mm)
Wikipedia GPR25 (Hs)
Tissue Distribution Comments
Northern blot analysis of poly(A)+ mRNA extracted from human tissues revealed no expression of GPR25 in liver and brain regions examined (basal forebrain, frontal cortex, thalamus, hypothalamus, amygdala, caudate, putamen, hippocampus, midbrain, medulla, cerebellum and pituitary) [1].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S360C
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs200080169
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S159L
Global MAF (%):  1
Subpopulation MAF (%):  AFR|AMR|EUR: 1|1|1
Minor allele count:  T=0.008/18
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs144298915
Validation:  1000 Genomes, Frequency

References

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1. Jung BP, Nguyen T, Kolakowski LF, Lynch KR, Heng HH, George SR, O'Dowd BF. (1997) Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1. Biochem Biophys Res Commun, 230 (1): 69-72. [PMID:9020062]

Contributors

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