Akt (Protein kinase B)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The action of phosphatidylinositol 3-kinase (PI3K), a downstream kinase activated by receptor tyrosine kinases, produces a series of phosphorylated phosphoinositides, which recruit 3-phosphoinositide-dependent kinase (PDPK1, O15530) activity to the plasma membrane, leading to activation of Akt. Akt may be activated by PIP3, PDK1-mediated phosphorylation [1] and mTORC2-mediated phosphorylation [6,11].

Enzymes

Akt1 (AKT serine/threonine kinase 1) Show summary » More detailed page

Akt2 (AKT serine/threonine kinase 2) Show summary » More detailed page

AKT3 (AKT serine/threonine kinase 3) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Akt (Protein kinase B). Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=285.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.