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Calcium- and sodium-activated potassium channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The 6TM family of K channels comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes herg channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [12]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).

Channels and Subunits

KCa1.1 C Show summary » More detailed page

KCa2.1 C Show summary » More detailed page

KCa2.2 C Show summary » More detailed page

KCa2.3 C Show summary » More detailed page

KCa3.1 C Show summary » More detailed page

KNa1.1 C Show summary » More detailed page

KNa1.2 C Show summary » More detailed page

KCa5.1 C Show summary » More detailed page

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Leonard K. Kaczmarek, Richard Aldrich, K. George Chandy, Stephan Grissmer, Aguan D. Wei, Heike Wulff, George A. Gutman. Calcium- and sodium-activated potassium channels. Accessed on 11/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=69.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Striessnig J, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Voltage-gated ion channels. Br J Pharmacol. 174 Suppl 1: S160-S194.