SLC29 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC29 family members appear to be composed of 11 TM segments with cytoplasmic N-termini and extracellular C-termini. ENT1, ENT2 and ENT4 are cell-surface transporters, while ENT3 is intracellular, possibly lysosomal [2]. ENT1-3 are described as broad-spectrum equilibrative nucleoside transporters, while ENT4 is primarily a polyspecific organic cation transporter at neutral pH [9]. ENT4 transports adenosine only under acidotic conditions [3].

Transporters

ENT1 (Equilibrative nucleoside transporter 1 / SLC29A1) C Show summary »

ENT2 (Equilibrative nucleoside transporter 2 / SLC29A2) C Show summary »

ENT3 (Equilibrative nucleoside transporter 3 / SLC29A3) C Show summary »

PMAT (Plasma membrane monoamine transporter / SLC29A4) C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

James R. Hammond. SLC29 family. Accessed on 26/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=216.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.