SLCO family of organic anion transporting polypeptides

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


« Hide

The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.


OATP1A2 / SLCO1A2 Show summary »

OATP1B1 / SLCO1B1 Show summary »

OATP1B3 / SLCO1B3 Show summary »

OATP1C1 / SLCO1C1 Show summary »

OATP2A1 / SLCO2A1 Show summary »

OATP2B1 / SLCO2B1 Show summary »

OATP3A1 / SLCO3A1 Show summary »

OATP4A1 / SLCO4A1 Show summary »

OATP4C1 / SLCO4C1 Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

Show »


Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Bruno Hagenbuch. SLCO family of organic anion transporting polypeptides. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.