Ligand id: 5082

Name: trastuzumab

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trastuzumab

Compound class Antibody
Approved drug? Yes (FDA (1998), EMA (2000))
International Nonproprietary Names
INN number INN
7637 trastuzumab
D5v8 | Herceptin® | R-597
Database Links
Specialist databases
IMGT/mAb-DB 97
Other databases
GtoPdb PubChem SID 178101775
PubChem SID 178101775
Search PubMed clinical trials trastuzumab
Search PubMed titles trastuzumab
Search PubMed titles/abstracts trastuzumab
Wikipedia Trastuzumab
Trastuzumab is a humanized IgG1κ monoclonal antibody targeting HER2.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Mylan laboratories Inc. and Biocon Limited are partnering the marketing of MYL-1401O (Hertraz®, Canmab®) a biosimilar already approved in India. A Biologics License Application (BLA) for MYL-1401O has been accepted by the FDA, and it is also under review by the EMA.
Herzum® (CT-P6; Celltrion Inc.) is approved in Korea. CT-P6 as Credima® is pre-registered with the EMA.
SB3 is in Samsung Bioepis' development pipeline.
HLX02 (Shanghai Henlius Biotech) is being evaluated in direct comparison to the originator product Herceptin® in Phase 3 breast cancer clinical trial NCT03084237.
Pfizer's PF-05280014 is also in Phase 3 development- see their REFLECTIONS B327-02 trial NCT01989676 for example.

Trastazumab antibody-drug conjugates (ADCs):
Trastuzumab emtansine is already approved for clinical use. It delivers a maytansinoid anti-tubulin toxin to cancer cells.
Trastuzumab duocarmazine (SYD985; Synthon Biopharmaceuticals) [1] delivers a toxic DNA methylating compound to target cells. It is in Phase 3 development.
Trastuzumab deruxtecan (DS-8201; Daiichi Sankyo) delivers a topoisomerase I inhibitor payload. It is in Phase 2 clinical development.