Ligand id: 6789

Name: etanercept

Compound class Antibody
Approved drug? Yes (source: FDA (1998), EMA (2009))
International Nonproprietary Names
INN number INN
7783 etanercept
Rhu Tnfr:Fc
TNR 001
Database Links
Specialist databases
IMGT/mAb-DB 216
Other databases
CAS Registry No. 185243-69-0
ChEMBL Ligand CHEMBL1201572
DrugBank Ligand DB00005
PubChem SID 135343504
Search PubMed clinical trials etanercept
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Search PubMed titles/abstracts etanercept
Wikipedia Etanercept
Etanercept is a TNFα inhibitor. It is a dimeric recombinant protein fusing the TNF receptor 2 to the Fc region of the human IgG1 antibody.

Biosimilar drugs: An etanercept biosimilar called etanercept-szzs (Erelzi®) is US FDA approved for all indications included in the reference product's label. Brenzys® (SB4; Samsung Bioepis) is approved in Korea and Canada and SB4 as Benepali® is approved in the EU.